The Binding of Isaac: Rebirth on Radeon R9 380X

Well above recommendedEstimate · low confidence, ±30%

Yes. The Radeon R9 380X is well above The Binding of Isaac: Rebirth's recommended spec. We estimate 300+ fps at 1080p high (range 300+, low confidence, ±30%), GPU-limited. At 1440p high expect 300+ fps, so every preset holds 60 fps. Model estimate, not measured; data updated 2026-09-24.

Estimated FPS by preset

Preset1080p1440p4K
low300+300+300+
medium300+300+288
high300+300+222
ultra300+296177
Estimate · low confidence, ±30%

Estimated FPS from our model (v0), based on the game's published requirements and relative GPU/CPU performance. Not measured. Real results vary with drivers, patches, and scenes. Values above 300 fps show as 300+. Data updated 2026-09-24.

Best settings

  • 60 fps at 1080p: ultra preset
  • 60 fps at 1440p: ultra preset
  • 144 fps at 1080p: ultra preset

AMD card: use FSR in quality mode before dropping the preset (XeSS also works). DLSS is not available on Radeon.

What limits performance

  • Estimates above: GPU-limited, assuming a processor fast enough not to hold the Radeon R9 380X back.
  • Processor needed for 300+ fps: Core i9-14900K or faster (slowest current desktop CPU our model expects to keep up).
  • With the recommended CPU: CPU-limited at 1080p high: about 90 fps instead of 300+.

Video memory

  • Radeon R9 380X: 4 GB
  • The publisher lists no video memory requirement.

The Binding of Isaac: Rebirth on popular graphics cards (high preset)

Graphics card1080p1440pvs Radeon R9 380X
GeForce GTX 1650300+300+-9%
Radeon R9 380X300+300+—
GeForce GTX 1060 6GB300+300++27%
GeForce RTX 2060 6GB300+300++91%
Radeon RX 6600300+300++109%
GeForce RTX 3060 12GB300+300++127%
GeForce RTX 4060 Laptop GPU300+300++136%
Radeon RX 7600300+300++164%
GeForce RTX 4060300+300++168%
GeForce RTX 3070300+300++214%
GeForce RTX 4070300+300++295%
Radeon RX 7800 XT300+300++341%
GeForce RTX 5070300+300++355%
Radeon RX 9070 XT300+300++491%
GeForce RTX 4080300+300++514%
GeForce RTX 5090300+300++877%

The Binding of Isaac: Rebirth on other hardware

More about the Radeon R9 380X

Specs and every game it runs →The Binding of Isaac: Rebirth requirements and FPS on popular hardware →Best GPUs for The Binding of Isaac: Rebirth →